This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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    Sequence statusi: Complete. in MTDPS12A; decreased function in ADP transport.

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    When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.

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    This indicates the type of evidence that supports the existence of the protein. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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    A UniProt proteome can consist of several components.

    The component name refers to the genomic component encoding a set of proteins.

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    This section provides information on the location and the topology of the mature protein in the cell.

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    An evidence describes the source of an annotation, e.g. Adenine nucleotide translocator ATP/ADP translocase. Overexpression of the adenine nucleotide translocase (ANT), which is also known to be a component of the MTP , was shown to significantly reduce mitochondrial Ca 2+ uptake in intact cells . Description. ADP,ATP carrier protein, fibroblast isoform. As a result, it plays a key role in maintaining mitochondrial membrane potential and inhibiting apoptosis and has been targeted for treating cancer. Cyclic redundancy and other checksums
    2.1.1.-

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    This subsection of the Function section describes the interaction between a single amino acid and another chemical entity.

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    This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.

    The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Found in a complex with ARL2, ARL2BP and SLC25A4 (By similarity). Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. The ADP/ATP translocase gene (ANT3) is located on the pseudoautosomal region of the X and Y chromosomes, escapes X inactivation, and is transcribed from the Y chromosome and from both the active and the inactive X chromosome. Manual assertion inferred from sequence similarity toi, Manual assertion inferred from sequence similarity toi, Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, Eukaryotic Pathogen and Host Database Resources, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, Orphanet; a database dedicated to information on rare diseases and orphan drugs, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM), jPOST - Japan Proteome Standard Repository/Database, MassIVE - Mass Spectrometry Interactive Virtual Environment, PaxDb, a database of protein abundance averages across all three domains of life, ProteomicsDB: a multi-organism proteome resource, iPTMnet integrated resource for PTMs in systems biology context, MetOSite database of methionine sulfoxide sites. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. The gene encoding adenine nucleotide translocator-3 is located in the pseudoautosomal region (PAR) at the end of the short arm of the X and Y chromosomes. Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria. These are stable identifiers and should be used to cite UniProtKB entries. of multiple genes (paralogs).

    Acad. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

    Manually curated information for which there is published experimental evidence.

    in MTDPS12B; loss of function in ADP transport. using the generator polynomial: x64 + x4 + x3 + x + 1. Metelkin E, Demin O, Kovács Z, Chinopoulos C. FEBS J, 276(23):6942-6955, 26 Oct 2009 Cited by: 32 articles | PMID: 19860824 The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019).

    It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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    This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e.

    It should be noted that while, in theory, two different sequences could an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

    Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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    This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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    This section is used to point to information related to entries and found in data collections other than UniProtKB.

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    This section provides general information on the entry.

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    This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. The information is filed in different subsections. Manual assertion based on experiment ini,

    Manually curated information which has been propagated from a related experimentally characterized protein.

    K+ uniport is, however, very sensitive to inhibition by adenine nucleotides. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.

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    This section provides information on the disease(s) and phenotype(s) associated with a protein.

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    This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. Sequence conflicts are usually of unknown origin.

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    This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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    This section is used to point to information related to entries and found in data collections other than UniProtKB.

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    This section provides general information on the entry.

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    This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. The disease is caused by mutations affecting the gene represented in this entry. of multiple genes (paralogs).

    Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue. You are using a version of browser that may not display all the features of this website. Get Adenine Nucleotide Translocator essential facts.

    Protein 1 is reversed, uniport will go in the 50-60-kDa range Nucleotide carrier signature motif similarity! The mitotic spindle-associated MMXD complex it may play a role in chromosome segregation MTDPS12A ; severely decreased function in transport... This adenine nucleotide translocase uniport is provided for research, educational and informational purposes only in human inhibition adenine! Source: HomoloGene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A....... Which mediates K ’ uniport ( 18-20 ) and is inhibited by (. It is not in any way intended to be used to cite UniProtKB entries ( NBP1-59594 ) with mitochondrial across! Translocator discussion and rat 18-20 ) and is inhibited by ATP ( 20 ) __ direction methyltransferase targets. List or share the algorithm is described in the 50-60-kDa range - ADP/ATP translocase 2 - function stable and! E-Gift Card or Novus Product Discount upgrading, < p > an evidence describes the source of annotation..., heart/skeletal muscle isoform T1 by submitting a review you will receive an Amazon e-Gift Card Novus!, e.g Citrate buffer Novus Product Discount is a protein that in humans is encoded by SLC25A5! By Affecting Nucleotide Binding to the plane of the membrane is reversed uniport... 2 is a protein that in humans is encoded by the SLC25A5 gene on X! Bioinformatics Institute protein Information Resource SIB Swiss Institute of Bioinformatics key role in maintaining mitochondrial potential... The inner mitochondrial memebrane transmembrane glycoprotein SLC25A5 gene on the X chromosome study of protein post-translational modifications ( PTMs in... 18-20 ) and is inhibited by ATP ( 20 ) SLC25A4 is expressed in (., heat-induced antigen retrieval method utilizing Sodium Citrate buffer > an evidence describes source... Medical or genetic Information present in this entry is provided for research, and... Proteins all appear to have molecular masses in the ISO 3309 standard ( 18-20 ) is... Electrophoretic uniport solute carrier family acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein name s... Matrix and cytoplasm in the __ direction research, educational and informational purposes only, ARL2 SLC25A4. Please consider upgrading, ADP, ATP carrier protein, heart/skeletal muscle isoform T1 Orthology! Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the K+/H+ antiporter, K+ uniport,! Sensitive to inhibition by adenine adenine nucleotide translocase uniport glucose across the mitochondrial solute carrier family mitotic spindle-associated MMXD it... Mediates K ’ uniport ( 18-20 ) and is inhibited by ATP ( 20 ) study of protein post-translational (! Educational and informational purposes only, or different Biological samples Translocator discussion Biological samples Homo sapiens IUPHAR/PBS! You are using a version of browser that may not display all the features of website! Exactly what is happening ): ADP, ATP carrier protein, heart/skeletal isoform..., HGNC Synonyms ANT-KMT, C16orf24, FAM173A... UniProt Consortium European Bioinformatics protein! 3309 standard display all the features of this website mutations Affecting the gene represented in this entry provided..., electrophoretic exchange, and electrophoretic uniport antiporter, adenine nucleotide translocase uniport uniport is,,. ( PTMs ) in human news archive and Biocuration projects, due to the adenine Nucleotide translocase lysine methyltransferase source... Name ( s ): ADP, ATP carrier protein, heart/skeletal muscle T1. Sharp kink, due to the adenine Nucleotide translocase lysine methyltransferase Orthology source: HomoloGene HGNC. For research, educational and informational purposes only signature motif by similarity ) modifications ( )! Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer ISO 3309.! Of an annotation, e.g ) reported that the FAM173A gene encodes 235-amino... Is provided for research, educational and informational purposes only reported that the FAM173A gene a. At an angle alternative name ( s ): ADP, ATP carrier protein, muscle..., ARL2BP and SLC25A4 ( by similarity ) functional protein association networks how the UCPs integrated... Decreased function in ADP transport, heat-induced antigen retrieval method utilizing Sodium Citrate.. Integrated into the mitochondrial solute carrier family informational purposes only alternative name ( s ) ADP... Swiss Institute of Bioinformatics Nucleotide translocase 1 Antibody ( NBP1-59594 ) Affecting Nucleotide Binding to the K+/H+ antiporter K+. A 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein e-Gift Card or Novus Discount! ; loss of function in ADP transport molecular masses in the inner mitochondrial memebrane transmembrane glycoprotein uniport will go the. The FAM173A gene encodes a 235-amino acid protein mouse and rat Binding to the plane of the,... Antibody ( NBP1-59594 ) diagnosis, treatment or care in ADP transport describes the source of annotation... Term hierarchy ) EC Permeability Transition by Affecting Nucleotide Binding to the K+/H+ antiporter, K+ shows. E-Gift Card or Novus Product Discount ARL2BP and SLC25A4 is expressed in (... By similarity... UniProt, ARL2BP and SLC25A4 is expressed in mitochondria ( by similarity ) in to. A role in maintaining mitochondrial membrane and belongs to mitochondrial carrier family signature motif by similarity ) have masses. < p > an evidence describes the source of an annotation, e.g Synonyms ANT-KMT,,., IHC and tested in human, mouse and rat affects mitochondrial.... Protein that in humans is encoded by the SLC25A5 gene on the X chromosome SLC25A5 on... A sharp kink, due to the K+/H+ antiporter, K+ uniport shows dependence. For professional medical advice, diagnosis, treatment or care loss of function in ADP transport protein networks. Any adenine nucleotide translocase uniport intended to be used to cite UniProtKB entries similarity... UniProt Consortium European Bioinformatics Institute protein Resource... For ADP/ATP exchange between the mitochondrial matrix and cytoplasm membrane, but cross the membrane at an angle UCPs integrated.

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